Destination guide

South America cruises

From Brazil’s Atlantic beaches to Patagonia’s fjords, the route shapes the trip. Compare Brazil, Argentina and Uruguay, Cape Horn, Pacific-coast calls and longer voyages between regions.

Find your cruise

Compare the route, departure port and ship. Select a cruise to see its ports on the map.

85 matching itineraries

  • Royal Caribbean

    6-Night Southern Caribbean

    Grandeur of the Seas · 6 nights

    From Cartagena

  • MSC Cruises

    Balneario Camboriu, Buenos Aires, Santos, Balneario Camboriu

    MSC Meraviglia · 6 nights

    From Balneário Camboriú

  • MSC Cruises

    Santos, Balneario Camboriu, Buenos Aires, Santos

    MSC Meraviglia · 6 nights

    From Santos

  • MSC Cruises

    Paranagua, Itajai, Ilhabela, Rio de Janeiro, Buzios, Paranagua

    MSC Musica · 6 nights

    From Paranaguá

  • MSC Cruises

    Itajai, Ilhabela, Rio de Janeiro, Buzios, Paranagua, Itajai

    MSC Musica · 6 nights

    From Itajaí

  • MSC Cruises

    Rio de Janeiro, Paranaguá, Itajai, Santos (Sao Paulo)

    MSC Musica · 6 nights

    From Rio de Janeiro

  • MSC Cruises

    Rio de Janeiro, Buzios, Paranagua, Itajai, Ilhabela, Rio de Janeiro

    MSC Musica · 6 nights

    From Rio de Janeiro

  • MSC Cruises

    Santos (Sao Paulo), Rio de Janeiro, Paranaguá

    MSC Musica · 6 nights

    From Santos

  • MSC Cruises

    Brazil, Uruguay, Argentina

    MSC Seaview · 6 nights

    From Balneário Camboriú

  • MSC Cruises

    Santos, Rio de Janeiro, Buzios, Salvador, Maceio

    MSC Virtuosa · 6 nights

    From Santos

  • MSC Cruises

    Salvador, Ilha Grande, Santos, Buzios, Salvador

    MSC Virtuosa · 6 nights

    From Salvador

  • MSC Cruises

    Santos, Buzios, Salvador, Ilha Grande, Santos

    MSC Virtuosa · 6 nights

    From Santos

Plan the route

Start with the part of South America you actually want to see

Compare the actual ports, scenic cruising days, sea days and embarkation city before comparing ships. A beach-and-city sailing on the Atlantic coast has a different pace, climate and packing list from a voyage around the southern tip of the continent.

Brazil, Argentina and Uruguay

Atlantic-coast routes combine Brazilian beaches and cities with calls such as Buenos Aires, Montevideo and Punta del Este. Some stay within Brazil; others cross borders. Check overnight calls and time ashore if city exploring matters most.

Patagonia, Cape Horn and the Chilean fjords

Southern voyages can connect Argentina and Chile via Ushuaia, Punta Arenas and scenic passages through fjords and glacier country. Cape Horn and some glacier or channel entries are scenic cruising rather than days ashore. Compare those days separately from port calls, and allow for changing weather.

The Pacific coast

Routes along Chile and Peru, sometimes continuing to Ecuador, pair coastal calls with access to inland cities. Callao serves Lima; San Antonio and Valparaíso are coastal gateways for Santiago. Check transfer distances before planning the day. Galápagos expedition itineraries are a distinct trip to compare separately.

Longer voyages and Antarctic extensions

Repositioning voyages may connect South America with Europe or North America and include many sea days. Some southern itineraries continue toward Antarctica or other South Atlantic islands. Antarctica is a separate continent: scenic cruising there and an expedition with planned landings offer different experiences. Check the route and landing arrangements rather than relying on the voyage title.

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Plan your time ashore

Find your port

Open a port guide for day plans, arrival advice, transport, practical information and tours.

61 ports

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Where cruises begin

South America departure ports

Buenos Aires, Santos and Rio de Janeiro are Atlantic gateways; San Antonio and Valparaíso serve Chile’s Pacific coast. Many longer voyages are one-way. Compare flights into both ends of the route, transfer distances and pre- or post-cruise hotel nights. A Santiago departure label refers to an inland city, so confirm the coastal embarkation port.

Balneário Camboriú · Barranquilla · Buenos Aires · Callao · Cartagena · Itajaí · Maceió · Paranaguá · Punta Arenas · Rio de Janeiro · Salvador · Santos · Ushuaia · Valparaíso

Port-day planning

Distances matter more than they look on the itinerary

Separate scenic cruising from days when you can go ashore. Fjords, glaciers and Cape Horn may be viewed from the ship, while tender calls and weather can change the usable time in port. Lima and Santiago require transfers from their coastal ports; major inland trips belong in a separate land extension. Use the port guides to compare terminal location and realistic outing times.

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Choose the experience

Then choose the ship

Once the route works, compare ship size, space per passenger, crew ratios, dining, pools and what the fare actually includes.

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South America cruise FAQ
Where do South America cruises go?

Atlantic-coast sailings link Brazil, Argentina and Uruguay. Southern routes explore Patagonia, Cape Horn and the Chilean fjords, while Pacific-coast voyages visit Chile, Peru and sometimes Ecuador. Longer voyages can connect these regions with other continents.

When should I cruise South America?

Patagonia and Cape Horn sailings generally focus on the Southern Hemisphere spring and summer. Brazil and the northern Pacific coast have different climates, so choose dates for the actual route rather than treating the whole continent as one season.

How long are South America cruises?

Regional Brazil, Argentina and Uruguay cruises can be about a week, while voyages around Cape Horn often take two weeks or more. Repositioning and multi-region itineraries can be much longer. Compare port days, scenic cruising and sea days in the day-by-day schedule.

Where do South America cruises depart from?

Common starting points include Buenos Aires, Santos and Rio de Janeiro on the Atlantic side, and San Antonio or Valparaíso on the Chilean coast. Ushuaia is also a gateway for Antarctic expeditions. Check the actual embarkation port: Santiago is inland, so a sailing marketed from Santiago requires a coastal transfer.

Does a South America cruise include Antarctica?

Usually it does not. Antarctica is a separate continent, although some voyages departing South America continue there. Check whether an itinerary offers scenic cruising only or an expedition with planned landings, and whether it crosses the Drake Passage. Landings and routes depend on conditions.

Can I explore South America cruise ports independently?

Some city calls suit independent exploring, but terminal location, tendering and travel time vary. Callao is the port for Lima, and Chilean embarkation ports are separate from Santiago. Distant inland sights may require a pre- or post-cruise stay rather than a normal port day.