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Complete Mississippi River Cruise

22 nights · American Serenade · 18 ports · 0 days at sea

1Day 1New Orleans

Your journey, day by day

Choose a day to explore the port and follow the route.

See the complete schedule
Day by day itinerary
DayPort
1United States
2
3United States
4United States
5United States
6United States
7United States
8United States
9United States
10United States
11
12United States
13
14United States
15
16United States
17
18United States
19United States
20
21
22United States
23United States

The map illustrates the route. Port times, where supplied, may change. Follow the ship’s all-aboard deadline on the day.

Your ship · American Cruise Lines

American Serenade

Guests
180
Built
2023
Full American Serenade guide →

What to pack

Typical weather ashore. Not a forecast.

Historical averages from NASA POWER. Check a forecast near departure.

Schedule supplied 2026-10-13. Ports and times are subject to change; the cruise line confirms the final itinerary.

Your sailing

Let’s get this cruise booked

From $14,890 per person

Checked October 13, 2026
Cabin categories, per person
Deluxe balcony$16,495
Premium balcony$17,540
Single balcony$18,200
Standard balcony$14,890
Deluxe balcony regular$17,495
Premium balcony regular$18,540
Single balcony regular$20,200
Standard balcony regular$15,890

Final fare, inclusions and cabin availability are confirmed as we arrange your booking.